College football by the odds: Vegas picks and preview of Week 1 That's the only place to start this year when it comes to Talking Points' Vegas pick 'em series every NFL game against the spread in the season. College football game picks, odds for Week 3: Roll with Notre Dame, Last week , I went 2- 1 on the picks, plus a win in the upset special. of this series would indicate that Notre Dame is in for a fight against one of those wins was by enough to cover the spread in this game. Pick: Notre Dame (). Pick Six: Breaking down Week 2 college football odds, best bets More than two -thirds of bettors had money on Baylor () against SMU. . Strangely, spread bets on Oklahoma (PK) are 3 to 1 in this game, but moneyline bets are 2 to 1 These teams are in year four of a year home-and-home series.